Études et publications

EPLS a réalisé de nombreuses études sous l’égide du Ministère des Affaires Etrangères Français, de la Communauté Européenne, et de l’Organisation Mondiale de la Santé (OMS). Depuis 1992, EPLS a réalisé plus de 50 programmes de recherche appliquée dans la vallée du fleuve, dont les résultats ont donné lieu à près de 100 publications dans des revues scientifiques et médicales internationales à comité de lecture.

Publications

Learning curve of vesico-urinary ultrasonography in Schistosoma haematobium infection with WHO practical guide: a "simple to learn" examination.

Bonnard P, Boutouaba S, Diakhate I, Seck M, Dompnier JP, Riveau G.

American Journal of Tropical Medicine and Hygiene, 2011, Dec;85(6):1071-4. (PMID : 22144446 )

In developing countries, it is difficult to rally a radiologist to conduct field studies. Here, we report how a radiologist taught a clinician to carry out the ultrasound examination as defined by the World Health Organization (WHO) record sheet for Schistosoma haematobium related lesions. In a population infected with S. haematobium, the learner and teacher performed two ultrasound exams and the results were compared. One hundred thirty-two children were prospectively included, during 8 ultrasonography sessions split over 23 days. After 51 examinations the learner's sensitivity was above 90%. After the fifth session the specificity reached 100% (results remained stable until the end of the study period). This study shows that a clinician can quickly learn how to carry out a simple ultrasound examination to gather the items needed for the follow-up of S. haematobium related lesions, suggesting that clinicians could implement networks of ultrasound-based surveillance on the field.

lire la suite..

A First attempt to validate the gSG6-P1 salivary peptide as an imuno-epidemiological tool for evaluating human exposure to An. funestus bites

Poinsignon A, Samb B, Doucoure S, Drame PM, Sarr JB, Sow C, Cornelie S, Maiga S, Thiam C, Rogerie F, Guindo S, Hermann E, Simondon F, Dia I, Riveau G, Konate L, Remoue F.

Tropical Medicine and International Health, 2010, 15(10):1198-203 (PMID : 20723184)

OBJECTIVE: The development of a biomarker of exposure based on the evaluation of the human antibody response specific to Anopheles salivary proteins seems promising in improving malaria control. The IgG response specific to the gSG6-P1 peptide has already been validated as a biomarker of An. gambiae exposure. This study represents a first attempt to validate the gSG6-P1 peptide as an epidemiological tool evaluating exposure to An. funestus bites, the second main malaria vector in sub-Saharan Africa. METHODS: A multi-disciplinary survey was performed in a Senegalese village where An. funestus represents the principal anopheline species. The IgG antibody level specific to gSG6-P1 was evaluated and compared in the same children before, at the peak and after the rainy season. RESULTS: Two-thirds of the children developed a specific IgG response to gSG6-P1 during the study period and--more interestingly--before the rainy season, when An. funestus was the only anopheline species reported. The specific IgG response increased during the An. funestus exposure season, and a positive association between the IgG level and the level of exposure to An. funestus bites was observed. CONCLUSIONS: The results suggest that the evaluation of the IgG response specific to gSG6-P1 in children could also represent a biomarker of exposure to An. funestus bites. The availability of such a biomarker evaluating the exposure to both main Plasmodium falciparum vectors in Africa could be particularly relevant as a direct criterion for the evaluation of the efficacy of vector control strategies.

lire la suite..

< Précédent 123456789101112131415161718192021222324252627 Suivant >