Études et publications

De Clercq D, Vercruysse J, Verlé P, Kongs A, Diop M.

Tropical Medicine and International Health, 2000, 5(10):744-6 (PMID : 11044270)

A group of 110 individuals with Schistosoma mansoni infection was investigated. Patients were allocated to one of three treatment groups and given artesunate or praziquantel alone or both in combination. Combined artesunate-praziquantel significantly increased the number of individuals cured at 5 weeks post-treatment, but at 12 weeks was only better than artesunate alone and at 24 weeks there was no statistically significant difference between the three groups. Egg count reduction rate was similar to the rate obtained with praziquantel used alone.

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de Clercq D, Vercruysse J, Sène M, Seck I, Sall CS, Ly A, Southgate VR.

Annals of tropical medicine and parasitology, 2000, 94(6):581-90 (PMID : 11064760)

The importance of the increase in irrigated land on the perimeters of the Middle and Upper Valleys of the Senegal River basin, on the prevalence and intensity of urinary schistosomiasis, was investigated. Surveys were conducted, in May-June 1997, to determine the prevalence and intensity of Schistosoma haematobium infection among 1445 children aged 7-14 years: 1011 in 10 villages near Matam, and 434 in four villages near Bakel. Macrohaematuria was present in seven of the study villages (four near Matan and three near Bakel), whereas microhaematuria was present in all the villages, with prevalences of 10%-73%. A second survey, conducted, in June 1999, on 755 children from nine of the study villages near Matam, demonstrated significant increases in the prevalences of both micro- and macro-haematuria in three of the villages, all of which were adjacent to the Senegal River and practising irrigated agriculture. None of the other study villages re-surveyed was irrigating any of its agricultural land. A longitudinal survey was also carried out, between May 1997 and November 1998, on about 10% of the population (2272 subjects) of Nguidjilone, north of Matam; selective treatment with praziquantel (40 mg/kg) was given in May 1997, and mass treatment in May 1998. The data analysed were those relating to the 125 individuals who provided samples at each survey. Very severe infections (> 1000 eggs/10 ml urine) were seen in five subjects in May 1997. One year later (i.e. 1 year after the selective treatment), the prevalence of urinary schistosomiasis had increased in every age-group. Although prevalence had decreased slightly by November 1998 (6 months after the mass treatment), the intensity of the infections seen had increased in every age-group. At the end of the dry season (May-June 1997), Bulinus truncalus infected with schistosome cercariae were recovered from the Senegal River. However, immediately after the next rainy season (November 1997), no snails were found at any collection site on the river.

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